Prof. Dr. Zoran Culig

Principal Investigators:

 Zoran Culig, Martin Puhr, Frédéric R. Santer, Julia Höfer

 Associated Researchers:

Zoran Culig – Florian Handle, Birgit Luef,  Andreas Bösl

Martin Puhr 

Frédéric R. Santer – Fabian Guggenberger, Kristina Trattnig, 

Alexander Oberhuber

 

The main focus of our laboratory is on progression of prostate cancer towards therapy resistance. There are many challenges in current prostate cancer research which remains one of the most frequently malignant tumors in male.

 

Prostate cancer growth stimulation by androgens is the basis for the development of new therapeutics in preclinical and clinical models. Our international enthusiastic group is very much interested in the mechanisms governing prostate cancer progression.

 

Androgenic hormones exert their effects through activation of androgen receptor which interacts with multiple coactivators. We have investigated functional significance of coactivators p300/CBP at different stages of prostate carcinogenesis. We and others could demonstrate that they enhance proliferation, migration, and invasion in prostate cancer.

 

Prostate cancer progression is also influenced by proinflammatory cytokines, such as interleukin-6. Cytokines are involved in epithelial to mesenchymal transition which is important for metastatic process.

 

We are also interested in the role of selected miRNA, such as miRNA 200 and 205 in regulation of chemosensitivity of prostate cancers. These processes are regulated in part by suppresors of cytokine signaling.

 

Projects in the laboratory are lead by four principal investigators, who are assisted by talented students and dedicated techicians. Frequent group meetings are essential for team spirit and successful completion of Ph.D. and master theses. Recently, we have extended our international collaborations thus contributing to success of European urological research. Our research has been recognized by international and Austrian scientific organizations and funding agencies by respected awards. We invite you to visit our home pages and become familiar with our research.       

© Robert Schober 2016